Hereditary Nonpolyposis Colorectal Neoplasms

A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Also Known As:

Hereditary Nonpolyposis Colorectal Cancer; Colon Cancer, Familial Nonpolyposis; Syndrome, Lynch; Lynch Syndrome; Familial Nonpolyposis Colon Cancer; Colorectal Neoplasms, Hereditary Nonpolyposis; Colorectal Cancer Hereditary Nonpolyposis; Hereditary Nonpolyposis Colon Cancer; Lynch Cancer Family Syndrome I; Lynch Syndrome I; Colon Cancer, Familial Nonpolyposis, Type 1; Colorectal Cancer, Hereditary Nonpolyposis, Type 1; Familial Nonpolyposis Colon Cancer Type 1; Hereditary Nonpolyposis Colorectal Cancer Type 1

Neoplasms: 1361496
- Hereditary Neoplastic Syndromes: 115
  - Hereditary Nonpolyposis Colorectal Neoplasms: 1268
- Neoplasms by Site: 4
  - Digestive System Neoplasms: 251
    - Gastrointestinal Neoplasms: 4515
      - Intestinal Neoplasms: 529
        Colorectal Neoplasms: 76245
        Hereditary Nonpolyposis Colorectal Neoplasms: 1268
Digestive System Diseases: 1068
- Gastrointestinal Diseases: 6062
  - Gastrointestinal Neoplasms: 4515
    - Intestinal Neoplasms: 529
      - Colorectal Neoplasms: 76245
        Hereditary Nonpolyposis Colorectal Neoplasms: 1268
  - Intestinal Diseases: 1640
    - Intestinal Neoplasms: 529
      - Colorectal Neoplasms: 76245
        Hereditary Nonpolyposis Colorectal Neoplasms: 1268
    - Colonic Diseases: 360
      - Colorectal Neoplasms: 76245
        Hereditary Nonpolyposis Colorectal Neoplasms: 1268
- Digestive System Neoplasms: 251
  - Gastrointestinal Neoplasms: 4515
    - Intestinal Neoplasms: 529
      - Colorectal Neoplasms: 76245
        Hereditary Nonpolyposis Colorectal Neoplasms: 1268
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 960
- Inborn Genetic Diseases: 12342
  - Hereditary Neoplastic Syndromes: 115
    - Hereditary Nonpolyposis Colorectal Neoplasms: 1268
Nutritional and Metabolic Diseases: 15
- Metabolic Diseases: 10634
  - DNA Repair-Deficiency Disorders: 544
    - Hereditary Nonpolyposis Colorectal Neoplasms: 1268

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